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AIVA User Guide

AIVA is your AI Clinical Analyst for whole genome interpretation. Upload FASTQ or VCF files, annotate and classify variants, review evidence with an AI agent that understands your data, and generate clinical-grade reports, all from a single platform.

Core Capabilities

  • Getting Started

    Create your account, learn the interface, upload your first sample, and choose a subscription tier.

    Get started

  • Samples and Uploads

    Upload VCF, CSV, and TSV files via drag-and-drop or cloud URLs. Optionally annotate with Small Variant Annotation or Structural Variant Annotation during upload.

    Manage samples

  • AIVA Chat

    Ask your AI assistant to query data, search literature, annotate variants, run Python code, explore knowledge graphs, and more.

    Start chatting

  • Data Table

    Filter, sort, and explore variant data at scale with a virtualized table built for millions of rows.

    Explore data

  • Analysis

    Perform tertiary analysis with category-based workflows, pharmacogenomics insights, and ACMG variant classification.

    Analyze data

  • Collaboration

    Create projects, invite team members with role-based access, flag variants, and hold threaded discussions at the row level.

    Collaborate

  • Reports

    Generate clinical reports with AI-assisted auto-fill, link samples, and export publication-ready documents.

    Build reports

  • Playbooks

    Browse, create, and share reusable analysis workflows.

    Browse playbooks

  • API Reference

    Programmatic access for uploads, chat, classification, exports, and MCP integration.

    View API docs

Resource Description
Account Setup Sign up, verify your email, and configure your profile
Uploading Your First Sample End-to-end walkthrough from file selection to data table
Subscription Tiers Compare Free, Trial, Plus, and Pro plans
AI Tools Reference Full list of tools available to the AIVA assistant
Variant Classifier Public ACMG/AMP variant classification tool
Compliance PHI detection, access controls, and data security
FAQ Answers to common questions

Who Is AIVA For?

  • Clinical geneticists triaging variants and writing diagnostic reports.
  • Research scientists exploring large WGS/WES datasets with AI assistance.
  • Bioinformaticians integrating AIVA into automated pipelines via the API.
  • Lab directors managing multi-user projects with audit-ready compliance.

Need help?

Open the Help modal from the header at any time, or visit the FAQ for answers to common questions.