Analysis Categories¶

Categories organize the Analysis Hub into focused workspaces, each containing a curated set of analysis cards relevant to a specific aspect of variant interpretation. AIVA provides built-in presets for common workflows and allows you to create custom categories tailored to your needs.

Built-In Category Presets¶

AIVA includes pre-configured categories for common analysis workflows:

Clinical Significance¶

Focus on variant pathogenicity assessment.

• ClinVar classification lookup
• Population frequency analysis (gnomAD)
• In silico prediction scores (CADD, SIFT, PolyPhen)
• ACMG criteria evaluation

Pharmacogenomics¶

Explore drug-gene interactions and prescribing implications.

• PGx card with drug-variant interactions
• PharmGKB data lookup
• Metabolizer status prediction
• Prescribing guideline references

Protein Function¶

Analyze the structural and functional impact of variants.

• Protein interaction networks
• Domain and structure mapping
• Conservation analysis
• Functional prediction scores

Phenotype Analysis¶

Connect clinical phenotypes to candidate genes.

• Phenotype association cards
• Phenotype-Gene Prioritization integration
• HPO term mapping
• Gene-phenotype correlation

Pathway Analysis¶

Explore biological pathway context for variants.

• Pathway membership lookup
• Network visualization
• Downstream effector analysis
• Drug target identification within pathways

Creating a Custom Category¶

1. Open the Analysis Hub.
2. Click New Category or the + button in the category selector.
3. Enter a category name and optional description.
4. Select the analysis cards to include in this category from the available card library.
5. Arrange the cards in your preferred layout.
6. Click Save.

The custom category appears in the category selector alongside the built-in presets.

Managing Categories¶

Editing a Category¶

1. Select the category you want to edit.
2. Click the category settings icon.
3. Add or remove analysis cards.
4. Rename the category or update the description.
5. Save your changes.

Reordering Categories¶

Drag categories in the category selector to change their display order.

Deleting a Category¶

1. Select the category.
2. Click the category settings icon.
3. Select Delete Category.
4. Confirm the deletion.

Category Workflows¶

Categories are designed to support structured analysis workflows. A typical approach:

1. Start with Clinical Significance: Assess pathogenicity of key variants.
2. Move to Pharmacogenomics: Check for drug-gene implications.
3. Explore Protein Function: Understand the molecular impact.
4. Review Pathway Analysis: Place findings in biological context.
5. Document in Reports: Use findings from each category in your report.

Tips¶

• Create task-specific categories: If you regularly perform a specific type of analysis (e.g., hereditary cancer panel review), create a category with exactly the cards you need.
• Share through projects: Custom categories created within a project are available to all project members.
• Combine with AIVA Chat: Use categories for structured analysis and AIVA Chat for ad-hoc questions and deep dives.