Clinical Trials¶
The Clinical Trials tool searches ClinicalTrials.gov directly from AIVA Chat. Use it to find trials relevant to specific genes, variants, conditions, or interventions, helping connect genomic findings to potential therapeutic opportunities.
Capabilities¶
- Search by condition: Find trials for specific diseases or syndromes (e.g., "hereditary breast cancer," "Lynch syndrome").
- Search by gene: Locate trials that mention specific genes in their eligibility criteria or study descriptions.
- Search by intervention: Find trials testing a particular drug, therapy, or procedure.
- Filter by status: Focus on recruiting, active, or completed trials.
- Filter by phase: Narrow results to Phase 1, 2, 3, or 4 trials.
- Retrieve trial details: Get titles, NCT numbers, sponsors, phases, enrollment status, and eligibility summaries.
Example Prompts¶
| Goal | Prompt |
|---|---|
| Gene-specific trials | "Are there any active clinical trials for TP53-mutated breast cancer?" |
| Drug-specific trials | "Find recruiting trials for olaparib in ovarian cancer." |
| Phase filtering | "What phase 3 trials are studying PARP inhibitors?" |
| Rare disease | "Are there any clinical trials for patients with PALB2 mutations?" |
| Combination therapy | "Find trials combining immunotherapy with targeted therapy for BRAF-mutated melanoma." |
| Eligibility | "What are the eligibility criteria for NCT04171700?" |
Understanding the Results¶
AIVA returns trial information in a structured format:
| Field | Description |
|---|---|
| Title | Official title of the clinical trial |
| NCT Number | Unique ClinicalTrials.gov identifier (e.g., NCT04171700) |
| Phase | Trial phase (Phase 1, 2, 3, 4, or combinations) |
| Status | Recruiting, Active not recruiting, Completed, Terminated, etc. |
| Sponsor | Organization leading the trial |
| Conditions | Diseases or conditions being studied |
| Interventions | Drugs, biologics, or procedures being tested |
Use NCT numbers for follow-up
If you find a trial of interest, you can ask AIVA for more details using its NCT number, or visit clinicaltrials.gov/study/NCTxxxxxxxx directly.
Common Use Cases¶
Connecting Variants to Trials¶
After identifying a pathogenic variant, search for trials that enroll patients with that specific mutation:
"I found a pathogenic BRCA1 variant. Are there any recruiting trials for BRCA1-mutated ovarian cancer?"
Exploring Treatment Options¶
When interpreting variants in actionable genes, find trials testing targeted therapies:
"What clinical trials are testing EGFR inhibitors for non-small cell lung cancer?"
Rare Disease Research¶
For uncommon conditions, clinical trials may represent the only therapeutic option:
"Find any clinical trials related to Fanconi anemia, regardless of phase or status."
Combining with Other Tools¶
Clinical Trials integrates naturally with other AIVA tools:
- Genomic Data Query + Clinical Trials: Query your data for actionable variants, then search for trials targeting those variants.
- Knowledge Graph + Clinical Trials: Find drugs that target a specific gene, then search for trials testing those drugs.
- Variant Annotation + Clinical Trials: Look up a variant's clinical significance, then find relevant trials for the associated condition.
- Web Search + Clinical Trials: Search for the latest treatment guidelines, then find active trials for recommended therapies.
See Example Workflows for end-to-end analysis patterns.
Limitations¶
- Results are sourced from ClinicalTrials.gov and may not include trials registered only on other registries (e.g., EU Clinical Trials Register, ANZCTR).
- Trial information reflects what is publicly registered. Enrollment status may not always be current.
- AIVA summarizes trial information but does not provide medical advice about trial eligibility or suitability.
Not a substitute for clinical judgment
Clinical trial results from AIVA are informational. Decisions about patient enrollment should involve the treating physician and the trial's principal investigator.